Nukleazaho, fermenthoest, ki kislotahoi nukleat (KN)-ro to mono va oligonukleotidho tajziya mekunand. Nukleazaho dar hujayrahoi mikroorganizmho, nabotot va hayvonot vase pahn shudaand. Nukleazaho khususan dar shirai gadudhoi zeri meda va obi dahoni shirkhurho khele bisyorand. Nukleazaho safedai massai molekulaashon nisbatan khurd buda, odatan khosiyati asosi dorand.
Roli biologii onho az hazm va tajziya kardani KN-i ba organizm begona (masalan, KN-i virusho) iborat ast. Roli Nukleazaho dar tanzim va sintezi KN niz khele kalon ast. Dar laboratoriya Nukleazahoro baroi toza kardani preparathoi az KN-i muayyan hosil kardashuda, muayyan kardani strukturai KN-i tadqiqshavanda va omuzishi mekhanizmi tajziya va sintezi onho istifoda mebarand.
Ad.: Shapot V. S., Nukleazi, M., 1968.