PROSTAGLANDINHO

PROSTAGLANDINHO     (az lotini glandule — gadud va prostata — pros­tata), guruhi moddahoi biogenii faoli fiziologie, ki dar yak qator uzvu boftahoi organizmi odam, hayvonot va baze rastaniho hosil meshavand. Prostaglandinhoro soli 1936 Eyler az nutfai odam judo kard. Solhoi okhir Prostaglandinho dar tarkibi digar uzvhoi badan niz yoft shudand. Prostaglandinhoi kholisro soli 1957 olimoni Shvetsiya Bergstrem va Shovall judo namudand. So­li 1962 olimi gollandi Dorp bo hamkoronash sokhti khimiyavii onro muayyan kard. Prostaglandinho ba guruhi kislo­tahoi hadnok mansuband. Asosi Prostaglandinho kislotai organiki buda, az zanjiri 20 atomi karbon, ki bo halqai siklopentani payvast ast, iborat meboshand.

Dar organizm Prostaglandinho az kislotlotahoi hadnok (beshtar az kislotahoi arakhidoni) dar zeri tasiri fermenthoi mikrosomii tarkibi hujayraho hosil meshavand. Alhol az tarkibi organizmhoi gunogun ziyoda az 20 Prostaglandinhoi tabbi chudo karda shudaast, ki ba 4 guhuh (A, V, E, F) taqsim meshavand; har yak guruh vobasta ba miqdori bandho boz ba guruhchaho judo shuda, bo raqamhoi 1 yo 2 ifoda meyobad, masalan, PA₁, va PA₂, PE₁,  va PE₂,  va gayra PA₁va PA₂ asosan dar gurda hosil shuda, paghoi dokhili onro vase va gipertoniyai ba illati gurda vobastaro bartaraf va PA₁, va PA₂ boshad, bronkhhoro vase va nafaskashiro oson menamoyand. Dar SSSR omuzishi Prostaglandinho az soli 1960 cap shud va alhol dar tib PG₂ khele mamul ast.

Akh: Mashkovekiy M. D.. Lekar­stvennie sredstva, MELOD, 1977; Prostagladinni, M., 1978.

Yu. N. Nuraliev.